|
Symbol Name ID |
Il6
interleukin 6 MGI:96559 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Impaired lymphocyte transformation with phytohemagglutinin |
Abnormality of neutrophils |
Leukemia |
Acute myeloid leukemia |
Severe periodontitis |
Keratoconjunctivitis sicca |
Lymphadenopathy |
Splenomegaly |
Subacute progressive viral hepatitis |
Cryoglobulinemia |
Autoimmunity |
Recurrent infections |
| Disease(s) Associated with IL6 | ||||||||||||||
| acute myeloid leukemia | ||||||||||||||
| aggressive periodontitis | ||||||||||||||
| hepatocellular carcinoma | ||||||||||||||
| Hodgkin's lymphoma | ||||||||||||||
| lymphoplasmacytic lymphoma | ||||||||||||||
| Sjogren's syndrome | ||||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
abnormal B cell proliferation |
increased susceptibility to induced colitis |
decreased pro-B cell number |
abnormal T cell differentiation |
abnormal lymphocyte cell number |
absent NK cells |
decreased T cell number |
abnormal T-helper 1 cell morphology |
abnormal effector T cell morphology |
abnormal microglial cell morphology |
microgliosis |
abnormal neutrophil physiology |
impaired neutrophil recruitment |
decreased IgA level |
decreased IgE level |
increased IgG2a level |
abnormal T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 2 physiology |
decreased cytotoxic T cell cytolysis |
abnormal macrophage physiology |
abnormal microglial cell physiology |
abnormal osteoclast physiology |
increased circulating interleukin-10 level |
decreased circulating interleukin-12 level |
abnormal acute phase protein level |
abnormal interferon level |
abnormal immune system physiology |
decreased interferon-gamma secretion |
decreased interleukin-17 secretion |
increased interleukin-4 secretion |
abnormal interleukin-6 secretion |
decreased susceptibility to induced arthritis |
abnormal inflammatory response |
decreased inflammatory response |
brain inflammation |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
increased susceptibility to fungal infection |
increased susceptibility to parasitic infection |
increased susceptibility to Poxviridae infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||
| Il6tm1Kopf/Il6tm1Kopf | ||||||||||||||||||||||||||||||||||||||||||||
| Il6tm1Kopf/Il6tm1Kopf Tg(Rorc-EGFP)1Ebe/? |
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| Il6tm1Mur/Il6tm1Mur | * | |||||||||||||||||||||||||||||||||||||||||||
| Il6tm1Poli/Il6tm1Poli | * | |||||||||||||||||||||||||||||||||||||||||||
| Tg(Gfap-Il6)G16Lms/0 Tg(Gfap-lacZ)1Lms/0 |
* | |||||||||||||||||||||||||||||||||||||||||||
| Tg(Gfap-Il6)G369Lms/0 | * | |||||||||||||||||||||||||||||||||||||||||||
| Il6tm1.1Jho/Il6tm1.1Jho Tg(GFAP-cre)8Gtm/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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